Anabolic effects of testosterone are preserved during inhibition of 5 -reductase
نویسندگان
چکیده
Stephen E. Borst, Christine F. Conover, Christy S. Carter, Chris M. Gregory, Emanuele Marzetti, Christiaan Leeuwenburgh, Krista Vandenborne, and Thomas J. Wronski Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center; Departments of Applied Physiology and Kinesiology, Aging and Geriatric Research, Physical Therapy, and Physiological Sciences, University of Florida, Gainesville, Florida
منابع مشابه
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase.
At replacement doses, testosterone produces only modest increases in muscle strength and bone mineral density in older hypogonadal men. Although higher doses of testosterone are more anabolic, there is concern over increased adverse effects, notably prostate enlargement. We tested a novel strategy for obtaining robust anabolic effects without prostate enlargement. Orchiectomized (ORX) male rats...
متن کاملInhibition of 5alpha-reductase blocks prostate effects of testosterone without blocking anabolic effects.
We studied the effect of the 5alpha-reductase inhibitor MK-434 on responses to testosterone (T) in orchiectomized (ORX) male Brown Norway (BN) rats aged 13 mo. At 4 wk after ORX or sham surgery, a second surgery was performed to implant pellets delivering 1 mg T/day or placebo pellets. During the second 4 wk of the study, rats received injections of MK-434 (0.75 mg/day) or vehicle injections. T...
متن کاملSingle dose testosterone increases total cholesterol levels and induces the expression of HMG CoA Reductase
BACKGROUND Cholesterol is mainly synthesised in liver and the rate-limiting step is the reduction of 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) to mevalonate, a reaction catalysed by HMG-CoA reductase (HMGCR). There is a comprehensive body of evidence documenting that anabolic-androgenic steroids are associated with deleterious alterations of lipid profile. In this study we investigated whe...
متن کاملThioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
Recently thioredoxin reductase 1 (TrxR1), encoded by Txnrd1, was suggested to modulate glucose and lipid metabolism in mice. Here we discovered that TrxR1 suppresses insulin responsiveness, anabolic metabolism and adipocyte differentiation. Immortalized mouse embryonic fibroblasts (MEFs) lacking Txnrd1 (Txnrd1(-/-)) displayed increased metabolic flux, glycogen storage, lipogenesis and adipogene...
متن کاملPrevalence of Anabolic Steroids among the Male Bodybuilding Athletes and Rate of Awareness to Side Effects in Shahrud
Aims: With the development of bodybuilding in Iran, abusing anabolic steroids has been a big problem. Also, the common and irreversible complications of these drugs for the athletes themselves are an important and controversial issue. The aim of this study was to investigate the prevalence of anabolic steroids and the awareness of male bodybuilder athletes and their coaches about the side effec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007